Upadacitinib Reduces Crohn's Disease Symptoms Within the First Week of Induction Therapy. pubmed.ncbi.nlm.nih.gov/38492903/

KONO-S Fabrizio Michelassi RCT PRELIMINARY at ONLY 3-6 month results - NO EFFECT - study will continue for 5 years #Crohn #ECCO24 #ECCO2024 #SoMe4IBD #SoMe4Surgery #IBD Surgery #IBD Crohn's & Colitis Foundation

SPICY: Hot off the press at #ECCO2024 / first RCT of mesenteric excision for ileocolic #Crohn #IBDSurgery -> no effect on postop endoscopic recurrence from #AmsterdamMedicalCenter

📢 📢 New American Gastroenterological Association (AGA) guidelines on Fecal Microbiota-Based Therapies 💩💩💩 for Select Gastrointestinal Diseases 📢 📢

➡️ gastrojournal.org/article/S0016-…

🔥🔥A tweetorial for #GITwitter , published in Gastroenterology 🔥🔥

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Stem cells safe and effective in pediatric perianal CD Amy Lee Lightner, MD
Jacob Kurowski. 83% clinical and 🩻 healing at 6 mo bit.ly/3U4k0nH

Check out our updates on the recent advances in prediction, prevention, monitoring, and treatment of postoperative Crohn’s disease; highlighting the most recent data over the last 5-10 years!

Thanks to Ben Click for the chance to work on this update!

link.springer.com/article/10.100…

More data supporting ileocecal resection over medical therapy for ileal Crohns. ⁦Manasi Agrawal, MD, MS⁩ ⁦Millie Long⁩ ⁦Edward Loftus⁩ ⁦GUILD Conference⁩

Does DLI/type of surgery (🔪) predict anastomotic stricture (AS) in CD? Benjamin Cohen MD MAS Ben Click AJG - The American Journal of Gastroenterology

🟠Caveats. yes. but good question + history.

✅AS = 18% ~3 yrs
✅DLI + type of 🔪 do not predict AS.
🟢this is what I expect in the biologic era.

journals.lww.com/ajg/fulltext/2…

Check out our multi-institutional, real world cohort validating risk factors for surgical POR. Congrats Ravi Shah !!

📢 American Gastroenterological Association (AGA) guidelines on management of inflammatory pouch disorders using GRADE
➡️ gastrojournal.org/article/S0016-…

🔥An #IBD tweetorial by Edward Barnes MD MPH, Manasi Agrawal, MD, MS, Gaurav Syal, MD MHDS, Ashwin,M.D, John Haydek, MD MS, Laura Raffals, MD and colleagues, published in Gastroenterology (1/11).

The advent of numerous MOA's in the IBD landscape lend themselves to unique SE/AE profiles. Shubha Bhat, PharmD & Ben Click provide some stratification of different agents as they relate to different patient specific factors. bit.ly/48rflBb

Press release of the SEQUENCE study is out

⚫️Head-to head phase 3 study of risankizumab vs ustekinumab in anti-TNF exposed patients with Crohn’s disease

⚫️ Risankizumab met both primary endpoints of non-inferiority for clinical remission and superiority of endoscopic remission

Our multicenter study comparing effectiveness of #upadacitinib vs #ustekinumab for UC induction in CGH:

doi.org/10.1016/j.cgh.…

🔑⬆️odds clin response and steroid-free clin remission at 8-16 wks for upa
🔑⬆️odds endo remission within 52 wks for upa

Brigham and Women's GI UNC Gastroenterology

Health care is making Americans poorer. In NEJM, we describe the current burden of medical debt, the history of our health financing system, and solutions to endemic medical debt in the US.

nej.md/3P1X2tc

1/10

Study finds upadacitinib therapy reduces #ulcerative colitis symptoms as early as day 1 of induction treatment. Learn more at ow.ly/La0S50Pv74z

Take a look at our recent study in Digestive Diseases and Sciences from Terry Li, MD NYU Langone Health and Cleveland Clinic on real-life monitoring of postoperative #Crohnsdisease !
Ben Click Benjamin Cohen MD MAS Salam Bachour #IBD

link.springer.com/article/10.100…

And commentary by David Fudman, MD rdcu.be/diQke

Our multicenter real-world experience w/ #upadacitinib induction for #UC in IBDJournal & CC360

🔑64% steroid-free remission
🔑84% clinical response
🔑62% endo response
🔑35% endo remission

doi.org/10.1093/ibd/iz…

Jessica R Allegretti, MD, MPH, FACG, AGAF The Allegretti Lab Brigham and Women's GI Edward Barnes MD MPH UNC Gastroenterology

📢 New AGA guidelines on biomarkers for ulcerative colitis (UC).

bit.ly/3md5H1X

🔥A Tweetorial for #GITwitter by American Gastroenterological Association (AGA) and Gastroenterology. #IBD

Ashwin,M.D Benjamin Cohen MD MAS Fernando Velayos MD MPH Shahnaz Sultan Shazia Siddique MD MS Jeremy Adler, MD, MSc (he/him)

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