Delighted that Nucleome is showcased as one of the 50 companies in PwC UK’s 'Life Sciences Future 50' report, illustrating the world-class science and innovation being led by the UK’s life sciences sector.

Read the report here: bit.ly/3Fnw379

We are looking for an RA to join the lab to work on a fantastic genomics project!

jobs.ac.uk/job/DCH089/res…

Closing date next week!

Please RT - thank you!

Very exited to share that our work showing the importance of SOX2 pioneer activity for gene activation has now been published in The EMBO Journal. Excellent work from MichEla and Teun van den Brand. And a nice collaboration with James Davies (+lab). embopress.org/doi/full/10.15…

Very happy and honored to present our work from my postdoc project in Noordermeer lab 🇺🇦 lab I2BC Paris-Saclay on CTCF clustering at TAD boundaries and the novel multi-contact 3C assay: Nano-C – now published Nature Communications.

nature.com/articles/s4146….

A nice 🧵 written by Daan 👇

Delighted to share our new approach for high fidelity sc genotyping combined with scATAC - called GTAC! Do check it out! We love it. Great collaboration with the Hughes and Davies labs also in the WIMM. Credit to Sven, Asger, Angus and all co-authors.

cell.com/cell-stem-cell…

We are excited to share our recent work mapping the host response to sepsis at single-cell resolution. The study, led by Andrew Kwok and published in Nature Immunology, identifies a subset of immature neutrophils which is increased in severe sepsis.

Big thanks to everyone involved!

The Clinicogenomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia ascopubs.org/doi/10.1200/JC…

TAL1 non coding mutations predict induction failure and poor outcome in T-ALL.

Terrific work from Marc Mansour and colleagues.

#efficacy #genome #editing exa-cel Vertex Pharmaceuticals leading to abrogation disease manifestations most #patients #thalassaemia & #sicklecell #EBMT2023 The EBMT #presidential ; Imperial NHS 💙 Imperial Department of Immunology & Inflammation part of this work

Honoured to be able to present our work in the jdavieslab MRC WIMM using adenine base editors to highly-efficiently correct HbE/beta-thalassaemia, which makes up approx 50% of all severe beta-thalassaemia worldwide, a short 🧵on our international effort! 1/10

In 2016 I looked after a girl who died during a transplant for HbE beta-thalassaemia.
I am overwhelmingly pleased that we have been able to correct HbE with near 100% efficiency using base editors.
nature.com/articles/s4146…
Brilliant work from Mohsin Badat Mohsin Badat jdavieslab

The Huntly lab CRUK Cambridge Centre: Haematological Malignancies has an opening for a research associate in bioinformatics. Great science, tonnes of data and a lovely team. Please RT.

jobs.cam.ac.uk/job/40423/

Really pleased to see our Nature Protocols paper out this week. We have put together a comprehensive guide to generating base resolution 3C data!

Hangpeng Li James Davies jdavieslab

Congratulations Joseph Hamley and Hangpeng Li for putting together a nature protocols paper for Micro Capture-C! nature.com/articles/s4159…

James Davies The EBMT

Cofactor requirements for transcription factors! A labour of love for Charlie Bell - so very proud of him and all in The Dawson Lab involved. A body of work that is not only amazing in scale but also tackles an important and tough question in our field - Enjoy!

Delighted and honoured to receive the ASH Abstracts Achievement Award for our oral presentation at this year's ASH meeting! Very grateful for the mentorship paresh vyas and to my fantastic colleagues at the MRC WIMM. This was a true team effort! #ASH22

Delighted to have you joining the lab!

Only ~2% of the human genome codes for proteins.

A Wellcome Discovery award for Jim R. Hughes jdavieslab and Cecilia Lindgren aims to deepen our understanding of the other 98% and its role in disease.

Big Data Institute MRC WIMM

Music: MNDLSS

A new Wellcome Discovery award project aims to use Micro Capture-C and Deep Neural Network Machine Learning to decipher the role of the non-coding genome in disease.

Jim R. Hughes. jdavieslab MRC MHU
Cecilia Lindgren Big Data Institute

bit.ly/3D7B1oK

Really excited to work on this project with Cecilia Lindgren and Jim R. Hughes! Wellcome wellcome.org/grant-funding/…