A word we hear a lot about currently in the trials world is #Estimands .  But what are they and why are they useful? 1/8
#MethodologyMonday #85

👯Not only do we love conference season for all of the clinical pearls we consume, but it’s pretty cool to spend time with our team. We’re working hard to bring you some new episodes that recap these conferences! 😎
#SHM2024 #IM2024 @societyhospmed @acpimphysicians #MedEd

Very illuminating and persuasive read!

Long-acting octreotide reduces bleeding in patients with gastrointestinal angiodysplasia. jwat.ch/3UpLPa4

Rahul Ganatra

We issued the first retraction in Hepatology Communications history last week

It is being processed by the publisher

But I thought I would share some thoughts

Still riding the high of convincing the rest of them to do this! ❤️

Rahul Ganatra Alice Gallo, MD ACP Yes, I check it every time I see a new shocky patient and see if it improves with tx, though not q30min.

Easy, free, fast, and informative. I’m a fan of Matt Siuba “shock BUS” to screen and then use a pump, pipes, tank approach to dx.

Shameless plug for podcasts.apple.com/us/podcast/pul…

Great reminder from Alice Gallo, MD at ACP #IM2024 about the ANDROMEDA-SHOCK trial:

pubmed.ncbi.nlm.nih.gov/31574228/

🔑 Capillary refill time (CRT) assessed q30 min guides resuscitation BETTER than lactate measurement q2h!

Critical care folks, are you using CRT?

No Benefit of Beta-Blockers in Revascularized Patients with Normal Ejection Fraction After MI
The era of “beta-blockers for all” after acute myocardial infarction may be ending, writes Dr Fred. jwat.ch/49trrcb

NEJM #ACC24

Sequential Time to Positivity as a Prognostic Indicator in Staphylococcus aureus Bacteremia

🔓 Open Access
bit.ly/49z0cgo

A digital book that transitions seamlessly between being an audiobook when you want to listen, and an ebook when you want to read.

Does this exist?

The test characteristics are terrible, BUT the hypothesis is really cool:

Can dogs detect exhaled biomarkers of stress (VOCs) in the breath of humans with PTSD?

frontiersin.org/articles/10.33…

The long-awaited publication of EPIC-SR, almost 2 years after the press release, should spark discussion about the responsibility for drug manufacturers to publish in a timely fashion.

We can speculate on reasons, but we can also clearly define the impact and consequences.

I'm SO proud of my badass wife Kate Robb, whose invited commentary in this issue of Health Affairs highlights the untapped potential of housing inspection as a tool to improve public health. Check it out!!

👏 👏 ❤️

Are these large effect sizes plausible? Eager to read in detail!

🥞 Hotcake #1: E-cigarettes for smoking cessation: ESTxENDs Paul Williams

Listen in to this hotcake from our most recent episode! What do you think? 🎧 #MedEd #medicine #ecigarette

New episode! 🎙️

🥞 #432 Hotcakes: E-cigarettes for smoking cessation, Gabapentin and COPD exacerbations, Lidocaine for neck pain, C diff risk by antibiotic type, and “dosing by clicks” for GLP1’s Rahul Ganatra Paul Williams Matthew Watto #MedEd #MedTwitter

Before modern lithium batteries, medical device makers had a big problem: how to power a pacemaker so it could last for years?

☢️ This is the forgotten story of NUCLEAR pacemakers & the secret technology developed by the CIA that made them obsolete. #tweetorial
1/