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The residual risk for death or HF hospitalization remains high at 5 years even for those who benefited from TEER. Patients like those enrolled in COAPT are sick. We should remind patients the underlying disease requires HF specialist attention.

nejm.org/doi/full/10.10…

Simona Visoiu Valva Mitralis Andreas Hagendorff Elena Romero You can say that again! Quite rightly said, dear friend Andreas Hagendorff 👏🏻👏🏻👏🏻
#COAPT 5-yr remains with more questions than answers. Many grey zones. It still leaves plenty to be desired. #FMR #TEER

MIЯVΛƬ #IC Henry Han , MBBS, MD KFAFHCards Fayez Baraah Mohamad Alkhouli Maurizio taramasso Nicole Karam, MD, PhD, FESC Dr. Gilbert Tang Colum Owens Khaled AlShaibi Mohamed Elsabah Ibrahim Bnsadiq Albakri , DRCPSC Harriette Van Spall, MD MPH Giuseppe Galati Giuseppe Biondi-Zoccai Giuseppe Di Gioia giulia masiero Mayra Guerrero, MD PCRonline 🫀 Good for your case. But honestly I don’t believe in #COAPT . So many grey zones in #GDMT quality and many disparities in echo values in suppl material. No sig diff between groups at 5 yr; Reg Vol calculated in only 9 pts, stroke vol 24mL, Many inconsistencies.

二次性僧帽弁閉鎖不全症に対する経カテーテル的僧帽弁クリップ術(mitraclip)。治療5年で心不全入院を約半減、遠隔期死亡率も有意に低下。無作為化比較試験COAPT試験の結果。 nejm.org/doi/full/10.10…

Original Article: Five-Year Follow-up after Transcatheter Repair of Secondary Mitral Regurgitation (COAPT): nej.md/3ZnFUlq

Editorial: Transcatheter Repair of Secondary Mitral Regurgitation nej.md/3N41Lej

#cardiology

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Editorial with 5 yr FU of #TEER in secondary #MR of #COAPT is nicely provided in the editorial NEJM by #JJV_McMurray and Marco Metra. Beware even with #TEER 3/4 of pts have hospitalisation or die in 5 years, and 57% are dead British Society for Heart Failure #theFword #CardioTwitter doi.org/10.1056/NEJMe2…

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5 yr FU results of #TEER #COAPT trial NEJM: lower HF hospitalisation + all cause mortality in #HFrEF +secondary (mod-severe or severe) #MR British Society for Heart Failure #theFword Sheffield Uni - IICD 🦠 💉 🫀💙 Chris Malkin #CardioTwitter #CardioEd HFAPresident doi.org/10.1056/NEJMoa…

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🤔 How does our Gulf region experience compare with the latest #COAPT 5-year results on MitraClip for functional MR? 🌍 Find out during #GISValves2023 Session 3: Imaging Focused Mitral, 16:00-17:00! 🕓

🌟 Join our expert panelists as they dive into late-breaking trials, discuss…

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Updates to ventricular remodeling findings and interpretation have been made in the COAPT trial.

Read the updates here: bit.ly/3GYcMI0 #HeartFailure #cvSurg #cvGeri

Nicolas Merke AG5-Kardiovaskulärer Ultraschall Andreas Hagendorff Tuğba Kemaloğlu Öz, Assoc Prof Elena Romero Hani Mahmoud-Elsayed Benoy Shah MD Echolab_Bielefeld Ritu Thamman MD Julia Grapsa Corrado Fiore MD, FASE, FEACVI Vladyslav Kavalerchyk 🇺🇦 Alex Felix Jan Verwerft Ivan Stankovic Indeed, #GDMT is the first-line therapy, regardless the clip. In fact, TEER is useless without GDMT. This is the main concern with #COAPT exhibiting an extremely low & poor quality of GDMT,rendering the trial very unreliable.

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Among patients with heart failure and secondary mitral regurgitation, transcatheter edge-to-edge repair of the mitral valve was found to be safe and effective at 2 years of follow-up; longer-term outcomes are unknown.

Read the full COAPT trial Research Summary:

Ventricular Remodeling and Outcomes After Mitral Transcatheter Edge-to-Edge Repair in Heart Failure: The COAPT Trial
sciencedirect.com/science/articl…