I'm very excited to present the updates on our scan mode SynchroPASEF on the #bruker timsTOF at #ASMS2023 . If you want to discuss how the high specificity and efficency of SynchroPASEF improves high troughput or single cell workflows, then visit my poster WP 122 today. Matthias Mann Lab

Me and timsTOF Ultra #massspec

Today was the first day of installation for our 5th (!) mass spectrometer, the timsTOF HT from BrukerMassSpec. Can’t wait to fire this one up and try some experiments. We’re excited to officially become part of the Bruker fan club. 🤓

We are happy to present our recent work applying timsTOF in PASEF mode for cataloging peptides and proteins in CSF using 4D proteomics. We further utilized this to identify differentially abundant proteins in Alzheimer’s disease. #WileyProteomics

nPOP multiplexed sc sample prep increases throughput and preserves quantitative accuracy and coverage.

Depth on TimsTOF Ultra was median 3200 proteins/cell.

biorxiv.org/content/10.110…

Trying to get more confident compound annotations in your #MSimaging datasets? Check out our new preprint 'On-tissue dataset-dependent MALDI-TIMS-MS2 bioimaging' on the #timsTOF for IMS-resolved MS2 acquisition by mzmine and the SIMSEF tool doi.org/10.26434/chemr…

Congratulations to Jamie Butalewicz for a riveting talk about implementing 193 nm UVPD on a timsTOF. #ASMS2023

#ASMS2023 Houston was fascinating. Photo1, a device to explore space (interstellar measures) . Photo2 showing #TimsTOF Ultra that pushes limits of sensitivity in mass spec at single cell level. What do you see in common besides blue cranes, rockets and ions flying in a vacuum?

Work in progress Etienne Caron BrukerMassSpec Yale Department of Immunobiology
#proteomics #immunopeptidomics #singlecell #teammasspec #timsTOF #massspectrometry

With SIMSEF you acquire an MS1-MALDI image, run non-target feature detection in MZmine and let the SIMSEF scheduling module create the MS2 lists. From here, the SIMSEF script controls the BrukerMassSpec #timsTOF to acquire the MS2 data:

Will timsTOF SCP will be the answer for single cell proteomics? I had some discussion with Bruker and the technology seems to be amazing. I wish Australia was not so behind in technology compared to the rest of the world. Seems no core facility in Australia has this.

Interested in running hundreds of Plasma samples with excellent reproducibility and robustness? Explore the possibilities with micro flow and timsTOF! Join me at poster WP 133 for an in-depth discussion. #ASMS2023 #PlasmaSamples #MassSpec #Bruker #ISB

We were keep getting more and more requests for proteomics analysis for big batch of samples so we managed to install timsTOF pro 2 at our core facility and now we are ready for more MS analysis.

Excited to share our latest research on fragment ion intensity prediction for timsTOF #immunopeptidomics data analysis! Check out the preprint on #bioRxiv : biorxiv.org/content/10.110…

Also really proud to be in a @proteomicsnews blog post! Read about it here: proteomicsnews.blogspot.com/2023/08/fragme…

First day of training at the new TimsTOF 2 Pro. The Bruker Team, Benoit and Hunter, is doing an excellent job. Thanks to Maxime for organizing!

Best Friday ever BrukerMassSpec TimsTOF is here!!!

Hoping to improve the depth of your plasma #proteomics ? Researchers at Helmholtz Munich combined the ease of using our ENRICH-iST plasma preparation with the power of a Bruker timsTOF HT instrument to identify almost 1,600 protein groups. Learn more: ow.ly/Mo8250Rf0NB

Muy interesantes jornadas de jóvenes investigadores de la SEEM e-seem.org excelente presentación de Juan Gómez de BrukerMassSpec sobre Bruker Applied Mass Spectrometry y #timsTOF . Muchas Gracias.

On July 19, Parallel Squared Technology Institute (PTI) and Slavov Laboratory members visited Bruker's headquarters in Billerica, MA for a full-day training workshop. They had the opportunity to see various timsTOF models and learn best practices for their instruments.

Playing around with lysozyme on the timsTOF Pro for Matthew Eddy Protein Biophysics class. We can’t wait to show the class some amazing mass spec!! UF Chemistry