Loss of function mutations in LXRα occur in at least 1/450 people and are associated with evidence of liver dysfunction, implicating LXRα in the maintenance of human liver health stephen o'rahilly (its pronounced O-RA-hill-EEE) biorxiv.org/content/10.110…

There are few things more damaging to a schools reputation than allowing masked individuals to blockade campus and deny entry to other students. There is simply no excuse for this simple abdication of care and duty to all students. Shame on UCLA

More evidence of a big downward correction for value of Ivy League degrees. Other private schools aren't simialry affected.

twitter.com/JohnArnoldFndt…

The new powerful GLP-1 medicines at doses used for #obesity are relatively new. Yet the class of GLP-1 medicines is now 19 years old, with Exenatide approved for #T2D April 28 2005. We have millions of treatment years for this class. Happy birthday Exenatide/GLP-1 medicines!

Protests and free speech on campus, yes. Respect for all members of the university community, property, and the law, also yes. Vandalism, illegal activity, trespassing, hate speech, support for proscribed terrorist groups? No. It is not complicated McGill University

#weightloss may even be safe in women with BMI>40 #pregnancy #obesity

Tough times demand real leadership to uphold the law, preserve free but not hate speech, restore order, and outlaw terrorist-affiliated organizations “Mr. Trudeau himself, seems increasingly out of touch in the new world of division and extremism”. nytimes.com/2024/04/28/opi…

Once weekly #insulin is arriving. When will you use it? #Diabetes Diabetologia link.springer.com/article/10.100…

Potential health risks of #AI enabled wellness apps Nature Medicine nature.com/articles/s4159…

Adenylate cyclase AC3-AT acts as a cold-induced rheostat in BAT, limiting adverse consequences of cAMP activity during chronic BAT activation #obesity Nature Metabolism nature.com/articles/s4225…

A comprehensive study of immune cells in human #T1D using pancreas draining lymphatic tissues #diabetes biorxiv.org/content/10.110…

Pro-tip for hapless Uni Presidents. You give students (and Professors) acting in violation of the law 24 hrs to clear campus and respect all rules and regulations. If they fail to obey, you expel/fire them. This allows civility to return to your campus, classes/graduations resume

Recent events have also shown the world that a college professor is not necessarily a responsible, thoughtful, well educated, respectful, tolerant, or considerate role model. The academy is riddled with rotten apples who are poorly suited to educate our children

There will be several university administrators looking for employment in September. Failure to maintain student and campus safety, ignoring violation of university and jurisdictional laws, cancelling classes and graduation, allowing vandalism of university property=incompetence

An entrepreneurial lab-owning physician, a laboratory biochemist, an osteoporosis expert, an oncologist, a nutritionist, and an epidemiologist sat down at the bar and said-lets talk about #VitaminD testing academic.oup.com/edrv/advance-a…

Full text, with my annotations.
I recently wrote about this in Ground Truths
erictopol.substack.com/p/a-big-week-f…
And there's a podcast with Daniel J Drucker
erictopol.substack.com/p/daniel-druck…

Some clinical experience with teduglutide in young children with #shortbowelsyndrome link.springer.com/article/10.100…

Liraglutide reduces bowel frequency in 8 PPL with ileo-anal pouch anastomosis journals.lww.com/ajg/abstract/9…

Never forget the timeless classics. Thyroid hormone Nature Metabolism nature.com/articles/s4225…

The remarkable actions of SGLT2i beyond glucose #T2D #CKD #heartfailure Nature Reviews Nephrology nature.com/articles/s4158…