We are delighted to share the #tyrosine The Kinase Library, now in nature: nature.com/articles/s4158…

Tyrosine predictions and enrichment analysis are now available: kinase-library.phosphosite.org

#TheKinaseLibrary #KL #part2

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1/9

Enjoying the Lake District with Dr David Unwin whilst we discuss insulin and carbohydrates in type 2 diabetes.

The succinate/SUCNR1 axis is activated by high glucose and represents an amplifying pathway for #insulin secretion relevant to the hyperinsulinemia of prediabetic states Journal of Clinical Investigation jci.org/articles/view/…

Insulin evokes release of endozepines from astrocytes of the NTS to modulate glucose metabolism
biorxiv.org/content/10.110…

Registration to #EISG24_Helsinki 🇫🇮 Virtual Meeting is NOW OPEN! Do not miss this last chance to participate: 🚨Registration closes on June 17 🚨helsinki.fi/en/conferences…

Research reveals how environmental pollutants impact #bloodsugar regulation in mice. The aryl hydrocarbon receptor (AhR) in pancreas cells seems to be a key player. #Diabetes #Health

👩‍🔬🧑‍🔬Myriam Hoyeck Jenny Bruin Carleton University
🔗sciencedirect.com/science/articl…

Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics go.nature.com/4a9lMs8

Today, the Gov’t of Canada announced $140M for Canada’s Immuno-Engineering and Biomanufacturing Hub, led by University of British Columbia, to accelerate the development of #LifesavingMedicine for Canadians. Congrats to the 4 teams 🎉

Learn more: bit.ly/3JNF1Np

#ImmunoengineeringHub #CBRFBRIF

Really interesting thread. Thank you.

Professional advice for trainees: When you email a PI to apply for a position, do not ask us to click a link to see your CV. IT safety is a high concern for us, and we are not going to risk it to view your CV.

Instead, please attach a PDF. #AcademicTwitter #AcademicChatter

This Thursday 5/9 Christine Doucette on circadian clock, insulin, and diabetes.

The (almost) full program is now online with an amazing lineup of speakers!
#AACRPan24
Eileen M O’Reilly Mancias Lab Jash Datta, MD Teresa Zimmers Dr. Andrew Hendifar Tobias Janowitz Wantong Yao Mara Sherman Lab KenOliveLab Andrew Aguirre Channing Der Bryant Lab UNC Erica D. Pratt Michael Goggins…

Transcriptomics for Clinical and Experimental Biology Research: Hang on a Seq onlinelibrary.wiley.com/doi/10.1002/gg…

Many scientists were bioRxiv supporters from the outset 🙏🙏

But what's really amazing is the number who tell me they're 'converts' after initially being highly skeptical. Willingness to change one's mind based on evidence/logic always a good sign 😀

A metabolic atlas of the aging mouse

biorxiv.org/content/10.110…

Structural basis of TRPV1 #IonChannel modulation by endogenous bioactive lipids | Nature Structural & Molecular Biology buff.ly/4bkhYW0

Precision medicine for #PancreaticCancer : Characterizing the clinico-genomic landscape and outcomes of KRAS G12C-mutated disease
In JNCI from Wungki Park, MD MS Eileen M O’Reilly Rona Yaeger & colleagues Memorial Sloan Kettering Cancer Center
~1% of pancreatic cancers harbor G12C and may have a…

Our work shows the number of mutation-bearing lesions in the human pancreas is ~1000. The lifetime probability to develop pancreatic cancer: 1/60.

So, the probability for a single lesion to become cancer is minuscule: about 1/600,000.
(all approximate)

nature.com/articles/s4158…

Mass spec is moving towards the detection of full length proteins in single cells.

This progress is enabled by nanospray desorption electrospray ionization and single ion detection.

Big picture & further prospects: pubs.acs.org/doi/10.1021/ac…

A role for placental IGFBP1 deficiency in GDM pathogenesis #diabetes Nature Medicine nature.com/articles/s4159…