Susceptibility to a mucosal pathogen is #microbiome - &diet-dependent: #Akkermansia muciniphila increases susceptibility on a fiber-free diet but on a fiber-rich diet it confers resistance ➡️ embopress.org/doi/full/10.10…
Mahesh Desai Lab LIH_Luxembourg #gutmicrobiome #Akkermansia

Profiling #transcriptionfactor occupancy on native (not cross-linked) #chromatin provides a more unperturbed picture of TF retention & better explains dynamic #genomeorganization ➡️ embopress.org/doi/full/10.10… #CTCF

Interesting discussions on the benefits of interdisciplinary research for advancing science, how to make it work &what are the challenges when bringing different fields/people together #sbmc2024 #systemsbiology #systemsmedicine LiSyM-Cancer

Genome-wide analyses of epigenomic alterations induced by clinical kinase inhibitors (CKIs) in macrophages activated by inflammatory stimuli identify similarities &differences among CKIs, improve their annotations &show opportunities for repurposing: embopress.org/doi/full/10.10…

A #StructuralProteomics approach is applied to identify conformation-specific interactors of Rab GTPases & of the monomeric &fibrillar forms of #alphasynuclein ➡️embopress.org/doi/full/10.10… Picotti Lab IMSB_ETH
#MassSpec #ProteinProteinInteractions #proteomics

#MachineLearning models identify functional splice-switching oligonucleotides (SSOs) & predict the splicing factors inhibited. SSOs are developed for a new target in #TripleNegativeBreastCancer ➡️ embopress.org/doi/full/10.10… #alternativesplicing #breastcancer Envisagenics

#StructuralBioinformatics tools reveal novel specialized Type VI Secretion System effectors &their cognate immunity proteins, highlighting their utility over standard sequence-based tools ➡️ embopress.org/doi/full/10.10… Asaf Levy

🚨 Deadline alert! Today is the abstract deadline for #SpatialOmics24 ! Don't miss out on the chance to win the Mol Syst Biol Poster Prize. Submit your abstract before midnight 👉 vibbio.tech/3vKiiON #spatialomics #spatialproteomics #multiomics #spatialmetabolomics

We had a fun time writing this commentary! embopress.org/doi/full/10.10…

How can we better understand soil #ecosystems ? This Comment discusses the power of integrative approaches for understanding predator-prey interactions &for revealing how they shape #populationdynamics in soil communities ➡️ embopress.org/doi/full/10.10… Jordi van Gestel EMBL

Genome-wide #p53 protein stability screens provide a comprehensive view of the processes regulating wild type & mutant p53 & uncover potential targets for reinforcing wt p53 or targeting mutant p53 in cancer ➡️ embopress.org/doi/full/10.10…
Daniel Schramek University of Toronto #CRISPR

04/2024 Issue➡️embopress.org/toc/17444292/2…
Reviews on i) alternative splicing programs ii) plasmid-mediated #antibioticresistance
#microbiome , gene expression variation, #proteasome substrate identification...
Cover: spatiotemporal neural #stemcell diversity MDC-BIMSB JP Junker

Dynamic analysis of RNA-protein interaction rewiring across growth phases detects extensive reorganisation of the RBPome & reveals the RNA binding properties for 17 unannotated E. coli proteins ➡️ embopress.org/doi/full/10.10… E Villanueva Cambridge Biochemistry

New opportunities for life scientists in #Japan through an
agreement between EMBO and the Japan Science and Technology Agency JST 科学技術振興機構: embo.org/features/foste…

EMBO announces the launch of a pilot scheme to support Open Access #OA publication by life scientists performing their #research in #India .

embo.org/features/suppo…

A very interesting paper in EMBO Reports about the
repeated endosymbiotic acquisitions in kareniacean dinoflagellates (and the very 1st paper I edited in EMBO Press as part as the disciplinary expansion into Molecular Eco-Evo) embopress.org/doi/full/10.10…

Pleased to welcome participants of 'Biological Oscillators' to @EMBL! Find time to chat with Mol Syst Biol editor Maria Polychronidou or The EMBO Journal's Ieva Gailite about publishing your data in our journals.
#EESBioOsc EMBL Events
embl.org/about/info/cou…

Duplicated self-interacting proteins can interact with themselves (homomers) or one another (heteromers). Is natural selection required to keep homomers over heteromers (or vice versa)? Read more ➡️ embopress.org/doi/full/10.10… Christian Landry Université Laval #evolution

Analysis of GTEx data & perturbation experiments in yeast show that cellular energy regulates the effect of optimal codon usage on mRNA stability ➡️ embopress.org/doi/full/10.10…
gagneurlab TU München Pelechano lab Karolinska Institutet SciLifeLab #RNAbiology