Hit-to-Lead in drug discovery! The new chapter of the
EFMC
Best Practices in Med Chem series has just been released. As usual, the material is freely accessible for personal use or for use in further training or teaching material
efmc.info/hit-to-lead

Beautiful Inter football 🖤💙

Inter || #UCL

Odd (but powerful) business context for Principal Component Analysis (PCA):

PCA was instrumental in analyzing the K-means results that eventually led to a $15,000,000 lead scoring algorithm that I made for my last company.

PCA helped to visualize the K-Means similarity of RFQ…

Understanding P-Values is essential for improving regression models. In 2 minutes, learn what took me 2 years to figure out.

1. The p-value: A p-value, in statistics, is a measure used to assess the strength of the evidence against a null hypothesis.

2. Null Hypothesis (H0):…

Our paper on binding kinetics of #melatonin receptors now on the Journal of Pineal Research Wiley Neuro provides new data from radioligand dissociation, corroborated by free-energy simulations. UCM1014 in enantiopure form is also tested for the first time.tinyurl.com/yfhjzd6p

It took me 10 years to master all 24 of these statistics concepts. In the next 24 days, I'll teach them to you one by one (with examples of how I've used them in business contexts). Here's what's coming:

1. Probability Distribution
2. Regression
3. Hypothesis Testing
4. Central…

Our account has lost over 7,000 followers in December.

We continue to ask for your engagement. You create this incredible community and help us keep the memory alive.

Support Auschwitz Memorial and amplify our voice.

Bayes' Theorem is a fundamental concept in data science. But it took me 2 years to understand its importance. In 2 minutes, I'll share my best findings over the last 2 years exploring Bayesian Statistics. Let's go.

1. Background: 'An Essay towards solving a Problem in the…

Correlation is the skill that has singlehandedly benefitted me the most in my career. In 3 minutes I'll compress what I learned in 10 years of using correlation to solve business problems.

1. Correlation: Correlation is a statistical measure that describes the extent to which…

ROC and AUC are important concepts for evaluating classification models in business (e.g. lead scoring). In 6 minutes, I'll share what took me 60 days to figure out. Let's dive in.

1. ROC Curve: The ROC curve, which stands for Receiver Operating Characteristic curve, is a…

Understanding P-Values is essential for improving regression models. In 2 minutes, learn what took me 2 years to figure out.

1. The p-value: A p-value, in statistics, is a measure used to assess the strength of the evidence against a null hypothesis.

2. Null Hypothesis (H0):…

Principal Component Analysis (PCA) is the gold standard in dimensionality reduction with uses in business. In 5 minutes, I'll teach you what took me 5 weeks. Let's go!

1. What is PCA?: PCA is a statistical technique used in data analysis, mainly for dimensionality reduction.…

Logistic Regression is the most important foundational algorithm in Classification Modeling. In 2 minutes, I'll teach you what took me 2 months to learn. Let's dive in:

1. Logistic regression is a statistical method used for analyzing a dataset in which there are one or more…

Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity #DrugDesign #MolecularDynamics
pubs.acs.org/doi/10.1021/ac…
Laura Scalvini Francesca Galvani Alessio Lodola Università di Parma
#JCIM Vol63 Issue21 #PharamceuticalModeling

🤷🏼‍♂️🖤💙

📢📢📢We have an open position for a postdoctoral researcher (18 months). Chemists with experience and interests in medicinal chemistry, synthetic methodology
Apply:bandi.unipi.it/public/Bandi/D…
Department of Pharmacy, University of Pisa Susanna Nencetti
#chempostdoc

Presentati oggi i nuovi Prorettori e le nuove Prorettrici #unipr : una squadra di otto docenti a fianco del Rettore Paolo Martelli.
Prorettore Vicario Fabrizio Storti
unipr.it/node/103545

BREAKING NEWS
The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

Our Director, Andrea Cavalli, will present a talk on “Computational Approaches to Drug Discovery in the Era of Precision Medicine' at the next 'Get to Know Your Neighbors Seminar' organized by Center for Intelligent Systems CIS-EPFL !
🗓️ Oct. 2, 15:15-16:15 CEST
📍EPFL, Room INF 328
➡️ epfl.ch/research/domai…

More EFMC Best-Practice Webinars you can find here: efmc.info/best-practices