Very happy to share our most recent endeavor into circadian anti-tumor immunity:

Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacy: Cell cell.com/cell/fulltext/…

It's #WorldLiverDay !

To highlight the occasion, we caught up with Dr Nekisa Zakeri to hear about why it's important to focus on #LiverDisease , and the cutting edge research led by our Inflammatory Liver Disease theme.

Learn more: birminghambrc.nihr.ac.uk/our-research/i…

#LiverTwitter

Exciting news - we have a brand new website🎉

Check it out to find out about:
- our latest news & events
- our research themes & projects
- how we work with patients, the public, & partners
- useful resources for BRC members
...and much more.

👉 birminghambrc.nihr.ac.uk

This is a shattering read for any clinician who has their sights on a career in clinical academia in the UK which is hurtling towards extinction. 🦤
⚠️ 36% of CAs are aged >55
⚠️ 65% at Professor grade >55
⚠️<1% Black/Black British
⚠️ 76% of CAs are men
medschools.ac.uk/news/investmen…

New from us: quantitative MRI identifies early changes in bile duct disease over time in primary sclerosing cholangitis; even when other metrics associated with disease progression are yet to evolve.

NIHR Birmingham Biomedical Research Centre PSC Support

onlinelibrary.wiley.com/doi/10.1111/ap…

Elliot Tapper Older age is one of the biggest predictors of mortality on the WL. TBS may have contributed to decreased WL mortality by favouring older, sicker pts. However, younger pts with portal HTN, encephalopathy or AIH/PSC are living in purgatory on WL. Longterm QALYs data is needed

You will join renowned experts as they delve into systemic therapy, exploring topics such as patient experiences, first-line therapy selection for HCC, second-line therapy options, and ground-breaking advancements in treating Biliary Tract Cancer (BTC).

Are you a student? 🎓 Benefit from free registration to attend the ILCA Single Topic Workshop on 26-27 April in Madrid, Spain.

Prospective head-to-head comparison of non-invasive scores for diagnosis of fibrotic #MASH in patients with type 2 #diabetes →shorturl.at/tyTY6 via laurent Castera Cédric Laouénan Paradis valerie Czernichow Sebastien Journal of Hepatology #T2DM #NAFLD #MASLD #NASH #livertwitter #liverhealth

Four-year overall survival update from the phase III HIMALAYA study of tremelimumab plus durvalumab in unresectable hepatocellular carcinoma - Annals of Oncology annalsofoncology.org/article/S0923-…

Women are under-represented at senior levels in #academia globally, and across all #science disciplines, as shown by these 'scissor-shaped curves' ✂️

So how can we achieve #gender #equality ?

We discuss various strategies in this #Cell Commentary.. 🧵

cell.com/cell/fulltext/…

New #JITC position article and guidelines: Expert consensus guidelines on management and best practices for tumor-infiltrating lymphocyte cell therapy bit.ly/3wDpiNt Allison Betof Warner, MD, PhD Omid Hamid MD Krishna Komanduri, MD, FASTCT John Haanen IGOR PUZANOV Michael R Bishop Adam J. Schoenfeld

This #RareDiseaseDay we’re highlighting Uni of Birmingham research to support families with rare diseases. Dr Nekisa Zakeri’s study is investigating how to guide gamma delta T-cells to #livercancer cells and enhance their cancer killing function.

Hey petri dish party people!🧫

Throw back to our 2022 immune checkpoint blockade event! ⭐️

And throw forward to #TumourMicroenviornment24 ! 🌟

Get involved! Abstract deadline is on Monday (19th)! 🚨👇
bit.ly/3QP9E9n

Nekisa Zakeri Bending Lab BSI Congress & Events

Science is at its best when we ALL have a voice!

Happy International Day of Women & Girls in Science 🎉

All areas of science are enhanced and enriched by both the work and presence of women and girls in the discipline.

#WomenInScience #WomenInSTEM #WomenInScience Day

Katie Kelley resourcing to almighty Anubis to evaluate risks and benefits from adjuvant therapy in HCC #HCCLive24 Anjana Pillai Amit G Singal Vatche G. Agopian Anthony El Khoueiry Riad Salem

In our latest study, we used human precision-cut #LiverSlices ( #PCLS ) to model #Alcohol -related Liver Disease ( #ALD )
mdpi.com/2609950

Why it matters? 🌎 Real-world patient diversity for the development of novel therapeutic approaches! #livertwitter

Key findings⬇️

Good to see our ToRcH-UK paper in Frontline Gastro edition this month! Outcomes vary at non-specialist centres and less than 2% of patients are transferred to specialist centres (and less in 2024) - what do we do to improve the British Liver Trust BASL education feed

fg.bmj.com/content/15/1/3

🚨NEW PAPER!! It gives me great pleasure to say that our latest publication is now out in Nature Communications! 🥳🥳 Here we report a new form of #cellincell structure in which #CD8 T cells can express E-cadherin and invade biliary epithelial cells!
Link here! rdcu.be/dxcYC.

Basics and art of Immunosuppression in Liver Transplantation

A comprehensive review by Poudel et al
#LiverTwitter #Transplant
jcehepatology.com/article/S0973-…