La 3e rencontre d’éthique de la SFN dans le thème de la fin de vie en Neurologie!
Nous aurons l’occasion d’y présenter les résultats de l’enquête menée auprès des neurologues et de proposer des pistes de réflexion pour aborder ce sujet complexe

Why did America demolish the world's most beautiful train station?

And what it says about us... (thread) 🧵

“Time based approaches could make a big difference in tracking not only how effective new disease-modifying drugs are, but also in helping Alzheimer’s patients and their families to better understand the progression of the disease and how they can plan for it.”

I enjoyed taking on some very thoughtful questions from Science Friday about the new Alzheimer’s drugs.

“These men, these three guys and the four who are watching at home, and the thousand or so who are no longer with us, are finally being honored the way they should be for what they did in World War II.” nytimes.com/2024/03/21/us/…

I had a great time discussing dementia and FTD specifically as a disorder of consciousness with Jason Karlawish Andrew E. Budson, MD and Isaiah Kletenik! Thanks for having us American Neuropsychiatric Association (ANPA)

Ash Paul Lon S. Schneider, MD Andrew Lees Seb Walsh Simon Mead Robert Howard Jason Cohen Madhav Thambisetty Michael Schöll Vincent Planche Stefano L. Sensi Alberto J Espay Eric Widera, MD Nicolas Villain Kasper Planeta Kepp Timothy Daly, PhD Gill Livingston Ryan Townley Jesse F Ballenger (mastodon.world/@jfballenger) Jason Karlawish James Rupert Fletcher Adam M. Brickman Dr. Jennifer Manly Sarah Ackley, PhD Erin Prater Hannah Kuchler CTAD Howard Gleckman American Geriatrics Society Kathy Liu Richard Merrick Nancy Lundebjerg (she/her/hers) Nathaniel Chin U.S. FDA NICE Raymond Koopmans Kariem Ezzat Dr Ben Underwood NHS England Deborah Cohen Lars Lau Raket Lea T. Grinberg, M.D, Ph.D The Washington Post Alex John London Emily Largent Alice Tang Maria Glymour Apologies if this group has already seen this paper. It was referred to in an email from Alzheimer Europe just now. The range of tests, obviously not with the sophisticated biomarkers, is not dissimilar to the ones I requested as a junior 20 years ago. thelancet.com/journals/laneu…

Is the prefrontal cortex “mission control” necessary for consciousness? Melanie Boly If so, what happens to experience in frontotemporal dementia? Emma Rhodes, PhD Excited for our symposium on dementia & consciousness American Neuropsychiatric Association (ANPA) #Houston w/ Andrew E. Budson, MD Jason Karlawish

Lon S. Schneider, MD Andrew Lees cachuchas Seb Walsh Simon Mead Robert Howard Jason Cohen Madhav Thambisetty Michael Schöll Vincent Planche Stefano L. Sensi Alberto J Espay Eric Widera, MD Nicolas Villain Kasper Planeta Kepp Timothy Daly, PhD Gill Livingston Ryan Townley Jesse F Ballenger (mastodon.world/@jfballenger) Jason Karlawish James Rupert Fletcher Adam M. Brickman Dr. Jennifer Manly Sarah Ackley, PhD Erin Prater Hannah Kuchler CTAD Howard Gleckman American Geriatrics Society Kathy Liu Richard Merrick Nancy Lundebjerg (she/her/hers) Nathaniel Chin U.S. FDA NICE Raymond Koopmans Kariem Ezzat Dr Ben Underwood NHS England Deborah Cohen Lars Lau Raket Lea T. Grinberg, M.D, Ph.D The Washington Post Algorithmic identification of persons with dementia for research recruitment: ethical considerations tandfonline.com/doi/full/10.10… via Alex John London & Jason Karlawish & Emily Largent et al

Lon S. Schneider, MD Andrew Lees cachuchas Seb Walsh Simon Mead Robert Howard Jason Cohen Madhav Thambisetty Michael Schöll Vincent Planche Stefano L. Sensi Alberto J Espay Eric Widera, MD Nicolas Villain Kasper Planeta Kepp Timothy Daly, PhD Gill Livingston Ryan Townley Jesse F Ballenger (mastodon.world/@jfballenger) Jason Karlawish James Rupert Fletcher Adam M. Brickman Dr. Jennifer Manly Sarah Ackley, PhD Erin Prater Hannah Kuchler CTAD Howard Gleckman American Geriatrics Society Kathy Liu Richard Merrick Nancy Lundebjerg (she/her/hers) Nathaniel Chin U.S. FDA NICE Raymond Koopmans Kariem Ezzat Dr Ben Underwood NHS England Deborah Cohen Lars Lau Raket Lea T. Grinberg, M.D, Ph.D The Washington Post Alex John London Emily Largent Leveraging electronic health records and knowledge networks for Alzheimer’s disease prediction and sex-specific biological insights
nature.com/articles/s4358… via Alice Tang & Maria Glymour et al

VIRTUAL only PARC AGING CHAT Monday from 12-1pm EST on Zoom

With Yaakov Stern & Jason Karlawish

➡️ FRONTIERS in ADRD RESEARCH

Zoom details in graphic
Yaakov Stern Jason Karlawish
Columbia Aging Ctr ColumbiaNeuroscience CPRC Penn LDI Penn Memory Center UPenn Medical Ethics & Health Policy University of Pennsylvania Neurology Institute on Aging

Presidential candidates Joe Biden and Donald Trump have publicly shown moments of forgetfulness in recent weeks, but PMC Co-Director @JasonKarlawish argues in MedPage Today that these moments alone are not signs of cognitive impairment. bit.ly/3uF3OiM

Andrew Lees Robert Howard Lon S. Schneider, MD cachuchas Madhav Thambisetty Seb Walsh Michael Schöll Vincent Planche Stefano L. Sensi Alberto J Espay Eric Widera, MD Nicolas Villain Kasper Planeta Kepp Timothy Daly, PhD Gill Livingston Ryan Townley Jesse F Ballenger (mastodon.world/@jfballenger) Jason Cohen Jason Karlawish James Rupert Fletcher Adam M. Brickman Dr. Jennifer Manly Sarah Ackley, PhD FORTUNE TIME Erin Prater TIME Financial Times Hannah Kuchler CTAD NIH Alzheimer's Association Howard Gleckman American Geriatrics Society Kathy Liu Richard Merrick Nancy Lundebjerg (she/her/hers) Nathaniel Chin U.S. FDA NICE Raymond Koopmans Maastricht University Kariem Ezzat Dr Ben Underwood NHS England The Observer Deborah Cohen Ian Sample Gordon Guyatt Alzheimer's Biomarkers Show Specific Changes 20 Years Before Diagnosis: CSF and imaging markers changed in a temporal sequence medpagetoday.com/neurology/alzh… via Judy George

Research coordinator Valerie Humphreys and former research coordinator Kimberly Halberstadter presented work from Dawn Mechanic-Hamilton's lab at the INS meeting in New York City. Congratulations, Valerie and Kimberly!

Excited to share our symposium - “Neural Correlates of Consciousness in Dementia:
Neurodegenerative Disease as a Window into The Human
Experience” at the American Neuropsychiatric Association (ANPA) 34th Annual Meeting with Melanie Boly Jason Karlawish Andrew E. Budson, MD Emma Rhodes, PhD

Our new paper: tandfonline.com/doi/full/10.10… examining ethical issues with the use of algorithms to identify people with Alzheimer’s or related dementias for research purposes with Jason Karlawish Emily Largent Spencer Hey and Ellen McCarthy. #ai #ethics #bioethics

“Disease-modifying workgroups that do not follow these standards to minimize conflicts of interest, including the current Alzheimer's Association workgroup, should not be considered legitimate by the medical community.” #Alzheimer
agsjournals.onlinelibrary.wiley.com/doi/full/10.11…

Andrew Lees cachuchas Madhav Thambisetty Robert Howard Seb Walsh Michael Schöll Vincent Planche Stefano L. Sensi Alberto J Espay Lon S. Schneider, MD Eric Widera, MD Nicolas Villain Kasper Planeta Kepp Timothy Daly, PhD Gill Livingston Ryan Townley Jesse F Ballenger (mastodon.world/@jfballenger) Jason Cohen Jason Karlawish James Rupert Fletcher Adam M. Brickman Dr. Jennifer Manly Sarah Ackley, PhD FORTUNE TIME Erin Prater TIME Financial Times Hannah Kuchler CTAD NIH Alzheimer's Association Howard Gleckman American Geriatrics Society Kathy Liu Richard Merrick Nancy Lundebjerg (she/her/hers) Nathaniel Chin U.S. FDA NICE Raymond Koopmans Maastricht University Kariem Ezzat Dr Ben Underwood NHS England The Observer Deborah Cohen Senior NHS England figures raise concerns that roll out of new Alzheimer's drugs by NICE could cost UK taxpayer £1 billion per year & endanger the lives of patients with the disease
dailymail.co.uk/health/article… via Ethan Ennals

To avoid another Aduhelm mess, Dr. Jason Karlawish writes for STAT, the FDA must serve the public interest by ending the use of amyloid lowering as a surrogate worthy of drug approval. 'It must demand rock-solid clinical data.' bit.ly/492Brty

artsandhealth.ie/perspectives/h… Brilliant reflections on the value of the arts to, well, health. Well-being. Being.